Hyperosmolar therapy for regulation of cerebral edema and intracranial pressure

Background: Hyperosmolar therapy is an essential treatment method for increased intracranial pressure and cerebral edema. Mannitol hypertonic saline are frequently used in clinical practice; however, more helpful recommendations needed the optimal management of edema terms choice, dosage, timing these medications. This study aimed to introduce characteristics relative strengths two agents, i.e., mannitol saline, review data supporting their use various diseases.Current Concepts: reduces by removing water from brain tissue transferring it vascular space creating osmotic gradient. improves blood flow reducing hematocrit, decreasing viscosity, increasing deformability red cells. Hypertonic increases intravascular volume, transiently cardiac output, oxygen partial brain. has several advantages over mannitol, including quicker onset longer-lasting reduction pressure. However, no significant differences noted clinical, functional outcomes, or mortality between agents.Discussion Conclusion: Both effective Clinicians should be able select appropriate agent different situations based on available evidence patients’ individual medical conditions.